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PRMT1

GENERAL INFORMATION

Gene name

 PRMT1

Gene description

 Protein arginine methyltransferase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA069769 , CAB022550
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRMT1 (HGNC Symbol)

Synonyms

 ANM1, HCP1, HRMT1L2

Description

 Protein arginine methyltransferase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49675786 - 49689029

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126457 (version 83.38)

Entrez gene

 3276

UniProt

 Q99873 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99873

Antibodypedia

 PRMT1 antibodies

PROTEIN BROWSER
«
PRMT1-001
PRMT1-002
PRMT1-005
PRMT1-006
PRMT1-007
PRMT1-008
PRMT1-010
PRMT1-011
PRMT1-014
PRMT1-015
PRMT1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRMT1-001
ENSP00000375724
ENST00000391851
Q99873 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008168 [methyltransferase activity]
GO:0008170 [N-methyltransferase activity]
GO:0008276 [protein methyltransferase activity]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019899 [enzyme binding]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0031175 [neuron projection development]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0042054 [histone methyltransferase activity]
GO:0042802 [identical protein binding]
GO:0043985 [histone H4-R3 methylation]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
GO:0044822 [poly(A) RNA binding]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045653 [negative regulation of megakaryocyte differentiation]
GO:0046985 [positive regulation of hemoglobin biosynthetic process]
GO:0048273 [mitogen-activated protein kinase p38 binding]
GO:1900745 [positive regulation of p38MAPK cascade]
Show all
 353 aa
40.5 kDa 		No 0
PRMT1-002
ENSP00000433556
ENST00000532489
E9PKG1 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 325 aa
37.7 kDa 		No 0
PRMT1-005
ENSP00000406162
ENST00000454376
H7C2I1 [Direct mapping]
Protein arginine N-methyltransferase 1; Protein arginine methyltransferase 1, isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 371 aa
42.5 kDa 		No 0
PRMT1-006
ENSP00000432349
ENST00000529284
E9PNR9 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 160 aa
18.3 kDa 		No 0
PRMT1-007
ENSP00000432538
ENST00000527382
E9PQ98 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 205 aa
23.6 kDa 		No 0
PRMT1-008
ENSP00000434911
ENST00000528623
E9PMZ2 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 63 aa
7.4 kDa 		No 0
PRMT1-010
ENSP00000437273
ENST00000529836
E9PMW9 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 110 aa
12.2 kDa 		No 0
PRMT1-011
ENSP00000431957
ENST00000534465
E9PIX6 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 207 aa
23.8 kDa 		No 0
PRMT1-014
ENSP00000433480
ENST00000524771
H0YDE4 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 238 aa
26.9 kDa 		No 0
PRMT1-015
ENSP00000432788
ENST00000526224
E9PNR9 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 160 aa
18.3 kDa 		No 0
PRMT1-201
ENSP00000484505
ENST00000610806
A0A087X1W2 [Direct mapping]
Protein arginine N-methyltransferase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 285 aa
32.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.