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STAT5A

CANCER ATLAS

Gene description

 Signal transducer and activator of transcription 5A

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA027873
HPA042128
HPA049883
HPA051156
CAB003860

GENE INFORMATION

Gene name

 STAT5A (HGNC Symbol)

Synonyms

 MGF, STAT5

Description

 Signal transducer and activator of transcription 5A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42287547 - 42311943

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126561 (version 83.38)

Entrez gene

 6776

UniProt

 P42229 (UniProt - Evidence at protein level)

neXtProt

 NX_P42229

Antibodypedia

 STAT5A antibodies

PROTEIN BROWSER
STAT5A-001
STAT5A-004
STAT5A-007
STAT5A-008
STAT5A-009
STAT5A-011
STAT5A-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT5A-001
ENSP00000341208
ENST00000345506
P42229 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000255 [allantoin metabolic process]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001553 [luteinization]
GO:0001779 [natural killer cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0008284 [positive regulation of cell proliferation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019218 [regulation of steroid metabolic process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019915 [lipid storage]
GO:0030155 [regulation of cell adhesion]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0033026 [negative regulation of mast cell apoptotic process]
GO:0033077 [T cell differentiation in thymus]
GO:0038161 [prolactin signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043029 [T cell homeostasis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043434 [response to peptide hormone]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045621 [positive regulation of lymphocyte differentiation]
GO:0045647 [negative regulation of erythrocyte differentiation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046449 [creatinine metabolic process]
GO:0046543 [development of secondary female sexual characteristics]
GO:0046544 [development of secondary male sexual characteristics]
GO:0048541 [Peyer's patch development]
GO:0050729 [positive regulation of inflammatory response]
GO:0060376 [positive regulation of mast cell differentiation]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
GO:0061180 [mammary gland epithelium development]
GO:0070668 [positive regulation of mast cell proliferation]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 794 aa
90.6 kDa 		No 0
STAT5A-004
ENSP00000407327
ENST00000444283
C9JVV6 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 125 aa
14.7 kDa 		No 0
STAT5A-007
ENSP00000468749
ENST00000590949
P42229 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000255 [allantoin metabolic process]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0019530 [taurine metabolic process]
GO:0038161 [prolactin signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0046449 [creatinine metabolic process]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
Show all
 794 aa
90.6 kDa 		No 0
STAT5A-008
ENSP00000443107
ENST00000546010
P42229 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000255 [allantoin metabolic process]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0019530 [taurine metabolic process]
GO:0038161 [prolactin signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0046449 [creatinine metabolic process]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
Show all
 764 aa
86.9 kDa 		No 0
STAT5A-009
ENSP00000465437
ENST00000588868
K7EK35 [Direct mapping]
Signal transducer and activator of transcription
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 763 aa
87.4 kDa 		No 0
STAT5A-011
ENSP00000466320
ENST00000587646
K7EM17 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 229 aa
26.2 kDa 		No 0
STAT5A-012
ENSP00000464730
ENST00000590726
K7EIF9 [Direct mapping]
Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 141 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.