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SGPP1

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GENERAL INFORMATION

Gene name

 SGPP1

Gene description

 Sphingosine-1-phosphate phosphatase 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA053149 , HPA064908
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053149 A-431 Nucleoplasm
HPA053149 PC-3 Nucleoplasm
HPA053149 U-2 OS Nucleoplasm
HPA064908 A-431 Nucleus
HPA064908 PC-3 Nucleus
HPA064908 U-2 OS Nucleus

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000021054 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA053149 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 SGPP1

Synonyms

Description

 Sphingosine-1-phosphate phosphatase 1 (HGNC Symbol)

Entrez gene summary

 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

Chromosome

 14

Cytoband

 q23.2

Chromosome location (bp)

 63684214 - 63728039

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126821 (version 83.38)

Entrez gene

 81537

UniProt

 Q9BX95 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BX95

Antibodypedia

 SGPP1 antibodies

PROTEIN BROWSER
SGPP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGPP1-001
ENSP00000247225
ENST00000247225
Q9BX95 [Direct mapping]
Sphingosine-1-phosphate phosphatase 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0006668 [sphinganine-1-phosphate metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0030148 [sphingolipid biosynthetic process]
GO:0042392 [sphingosine-1-phosphate phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 441 aa
49.1 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.