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Gene name

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Chromosome

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In atlas

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Reliability

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Method

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Searches

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Specificity

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Detectable

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CPSF3L
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CPSF3L

Gene description

Cleavage and polyadenylation specific factor 3-like

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

17
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 2 antibodies.
HPA028379 , HPA029025
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0102030405060RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250Tags Per Million

GENE INFORMATION

Gene name

CPSF3L (HGNC Symbol)

Synonyms

CPSF73L, FLJ20542, INT11, INTS11, RC-68

Description

Cleavage and polyadenylation specific factor 3-like (HGNC Symbol)

Entrez gene summary

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1311585 - 1324691

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127054 (version 83.38)

Entrez gene

54973

UniProt

Q5TA45 (UniProt - Evidence at protein level)

neXtProt

NX_Q5TA45

Antibodypedia

CPSF3L antibodies

PROTEIN BROWSER

«
CPSF3L-001
CPSF3L-007
CPSF3L-009
CPSF3L-011
CPSF3L-016
CPSF3L-017
CPSF3L-023
CPSF3L-030
CPSF3L-031
CPSF3L-032
CPSF3L-034
CPSF3L-038
CPSF3L-201
CPSF3L-202
CPSF3L-203
CPSF3L-204
CPSF3L-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPSF3L-001
ENSP00000413493
ENST00000435064
Q5TA45 [Direct mapping]
Integrator complex subunit 11
A0A024R0F2 [Target identity:100%; Query identity:100%]
Cleavage and polyadenylation specific factor 3-like, isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016180 [snRNA processing]
GO:0016787 [hydrolase activity]
GO:0032039 [integrator complex]
GO:0072562 [blood microparticle]
Show all
600 aa
67.7 kDa
No 0
CPSF3L-007
ENSP00000464436
ENST00000421495
J3QRY6 [Direct mapping]
Cleavage and polyadenylation specific factor 3-like, isoform CRA_g; Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
342 aa
38.5 kDa
No 0
CPSF3L-009
ENSP00000404886
ENST00000419704
Q5TA45 [Direct mapping]
Integrator complex subunit 11
A0A024R073 [Target identity:100%; Query identity:100%]
Cleavage and polyadenylation specific factor 3-like, isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016180 [snRNA processing]
GO:0016787 [hydrolase activity]
GO:0032039 [integrator complex]
GO:0072562 [blood microparticle]
Show all
499 aa
56 kDa
No 0
CPSF3L-011
ENSP00000400548
ENST00000411962
C9IYS7 [Direct mapping]
Cleavage and polyadenylation specific factor 3-like, isoform CRA_i; Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
502 aa
56.3 kDa
No 0
CPSF3L-016
ENSP00000481275
ENST00000429572
A0A087WXT8 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
289 aa
31.2 kDa
No 0
CPSF3L-017
ENSP00000411233
ENST00000434694
C9J979 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
344 aa
39 kDa
No 0
CPSF3L-023
ENSP00000392848
ENST00000450926
Q5TA45 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016180 [snRNA processing]
GO:0016787 [hydrolase activity]
GO:0032039 [integrator complex]
GO:0072562 [blood microparticle]
Show all
578 aa
65.2 kDa
No 0
CPSF3L-030
ENSP00000436743
ENST00000527719
E9PI75 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
209 aa
23.3 kDa
No 0
CPSF3L-031
ENSP00000436824
ENST00000498476
E9PQF0 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
167 aa
18.1 kDa
No 0
CPSF3L-032
ENSP00000435772
ENST00000534345
E9PIL7 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
140 aa
15.7 kDa
No 0
CPSF3L-034
ENSP00000432009
ENST00000530031
E9PIG1 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
249 aa
27.4 kDa
No 0
CPSF3L-038
ENSP00000434790
ENST00000526332
E9PNH9 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
109 aa
12.4 kDa
No 0
CPSF3L-201
ENSP00000445001
ENST00000540437
Q5TA45 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016180 [snRNA processing]
GO:0016787 [hydrolase activity]
GO:0032039 [integrator complex]
GO:0072562 [blood microparticle]
Show all
606 aa
68.1 kDa
No 0
CPSF3L-202
ENSP00000444672
ENST00000545578
Q5TA45 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016180 [snRNA processing]
GO:0016787 [hydrolase activity]
GO:0032039 [integrator complex]
GO:0072562 [blood microparticle]
Show all
571 aa
64.7 kDa
No 0
CPSF3L-203
ENSP00000480957
ENST00000618806
Q96HV7 [Direct mapping]
CPSF3L protein; Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
389 aa
44.1 kDa
No 0
CPSF3L-204
ENSP00000481821
ENST00000620829
A0A087WYI0 [Direct mapping]
Integrator complex subunit 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
502 aa
56.3 kDa
No 0
CPSF3L-205
ENSP00000487303
ENST00000627245
A0A0D9SGA8 [Direct mapping]
Integrator complex subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
46 aa
4.9 kDa
No 0

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The Human Protein Atlas project is funded
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