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RGS13

GENERAL INFORMATION

Gene name

 RGS13

Gene description

 Regulator of G-protein signaling 13

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, tonsil, appendix)
GTEx:Tissue enhanced (small intestine)
FANTOM5:Group enriched (appendix, tonsil, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in lymhoid cells.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA044952
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, tonsil, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, tonsil, small intestine)

GENE INFORMATION

Gene name

 RGS13

Synonyms

Description

 Regulator of G-protein signaling 13 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q31.2

Chromosome location (bp)

 192636138 - 192660306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127074 (version 83.38)

Entrez gene

 6003

UniProt

 O14921 (UniProt - Evidence at transcript level)

neXtProt

 NX_O14921

Antibodypedia

 RGS13 antibodies

PROTEIN BROWSER
RGS13-001
RGS13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS13-001
ENSP00000375853
ENST00000391995
O14921 [Direct mapping]
Regulator of G-protein signaling 13
A0A024R989 [Target identity:100%; Query identity:100%]
Regulator of G-protein signalling 13, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
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 159 aa
19.1 kDa 		No 0
RGS13-201
ENSP00000442837
ENST00000543215
O14921 [Direct mapping]
Regulator of G-protein signaling 13
A0A024R989 [Target identity:100%; Query identity:100%]
Regulator of G-protein signalling 13, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
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 159 aa
19.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.