Expression of PLA2G5 in cancer - Summary

CANCER ATLAS

Gene description

Phospholipase A2, group V

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053361

GENE INFORMATION
Gene name	PLA2G5
Synonyms
Description	Phospholipase A2, group V (HGNC Symbol)
Entrez gene summary	This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	20028179 - 20091190
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127472 (version 83.38)
Entrez gene	5322
UniProt	P39877 (UniProt - Evidence at protein level)
neXtProt	NX_P39877
Antibodypedia	PLA2G5 antibodies

PROTEIN BROWSER

PLA2G5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G5-001 ENSP00000364249 ENST00000375108	P39877 [Direct mapping] Calcium-dependent phospholipase A2 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Disease related genes Potential drug targets Show all	GO:0004623 [phospholipase A2 activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0006663 [platelet activating factor biosynthetic process] GO:0008201 [heparin binding] GO:0009986 [cell surface] GO:0010518 [positive regulation of phospholipase activity] GO:0016042 [lipid catabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0034097 [response to cytokine] GO:0036148 [phosphatidylglycerol acyl-chain remodeling] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036150 [phosphatidylserine acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047498 [calcium-dependent phospholipase A2 activity] GO:0048471 [perinuclear region of cytoplasm] GO:0050482 [arachidonic acid secretion] GO:0051591 [response to cAMP] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	138 aa 15.7 kDa	Yes	0