Fields »
ABOUT
HELP
BLOG
PLA2G5

GENERAL INFORMATION

Gene name

 PLA2G5

Gene description

 Phospholipase A2, group V

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Tissue enhanced (ovary, heart muscle)
FANTOM5:Tissue enhanced (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, including heart muscle, placenta and retina.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053361
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

 PLA2G5

Synonyms

Description

 Phospholipase A2, group V (HGNC Symbol)

Entrez gene summary

 This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 20028179 - 20091190

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127472 (version 83.38)

Entrez gene

 5322

UniProt

 P39877 (UniProt - Evidence at protein level)

neXtProt

 NX_P39877

Antibodypedia

 PLA2G5 antibodies

PROTEIN BROWSER
PLA2G5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G5-001
ENSP00000364249
ENST00000375108
P39877 [Direct mapping]
Calcium-dependent phospholipase A2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006663 [platelet activating factor biosynthetic process]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016042 [lipid catabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0034097 [response to cytokine]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050482 [arachidonic acid secretion]
GO:0051591 [response to cAMP]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 138 aa
15.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.