Cell atlas - F2RL3 - The Human Protein Atlas

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F2RL3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	F2RL3
Gene description	Coagulation factor II (thrombin) receptor-like 3
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (HEL, HMC-1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEL, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	F2RL3 (HGNC Symbol)
Synonyms	PAR4
Description	Coagulation factor II (thrombin) receptor-like 3 (HGNC Symbol)
Entrez gene summary	Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16888860 - 16892606
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127533 (version 83.38)
Entrez gene	9002
UniProt	Q96RI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RI0
Antibodypedia	F2RL3 antibodies

PROTEIN BROWSER

F2RL3-001	F2RL3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F2RL3-001 ENSP00000248076 ENST00000248076	Q96RI0 [Direct mapping] Proteinase-activated receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0009611 [response to wounding] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0060155 [platelet dense granule organization] GO:0070493 [thrombin receptor signaling pathway] Show all	385 aa 41.1 kDa	Yes	7
F2RL3-003 ENSP00000471518 ENST00000599210	M0R0Y0 [Direct mapping] Proteinase-activated receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0007596 [blood coagulation] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0070493 [thrombin receptor signaling pathway] Show all	113 aa 12.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.