Tissue expression of F2RL3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	F2RL3
Gene description	Coagulation factor II (thrombin) receptor-like 3
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION
Gene name	F2RL3 (HGNC Symbol)
Synonyms	PAR4
Description	Coagulation factor II (thrombin) receptor-like 3 (HGNC Symbol)
Entrez gene summary	Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16888860 - 16892606
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127533 (version 83.38)
Entrez gene	9002
UniProt	Q96RI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RI0
Antibodypedia	F2RL3 antibodies

PROTEIN BROWSER

F2RL3-001	F2RL3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F2RL3-001 ENSP00000248076 ENST00000248076	Q96RI0 [Direct mapping] Proteinase-activated receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0009611 [response to wounding] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0060155 [platelet dense granule organization] GO:0070493 [thrombin receptor signaling pathway] Show all	385 aa 41.1 kDa	Yes	7
F2RL3-003 ENSP00000471518 ENST00000599210	M0R0Y0 [Direct mapping] Proteinase-activated receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0007596 [blood coagulation] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0070493 [thrombin receptor signaling pathway] Show all	113 aa 12.3 kDa	Yes	0