Cell atlas - SYNGR3 - The Human Protein Atlas

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SYNGR3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SYNGR3
Gene description	Synaptogyrin 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (HDLM-2, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042842
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042842	SH-SY5Y	Plasma membrane
	HPA042842	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	SYNGR3
Synonyms
Description	Synaptogyrin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1989660 - 1994275
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127561 (version 83.38)
Entrez gene	9143
UniProt	O43761 (UniProt - Evidence at protein level)
neXtProt	NX_O43761
Antibodypedia	SYNGR3 antibodies

PROTEIN BROWSER

SYNGR3-001	SYNGR3-003	SYNGR3-004	SYNGR3-005	SYNGR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNGR3-001 ENSP00000248121 ENST00000248121	O43761 [Direct mapping] Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008021 [synaptic vesicle] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] GO:0032411 [positive regulation of transporter activity] GO:0042169 [SH2 domain binding] GO:0045202 [synapse] GO:0047485 [protein N-terminus binding] Show all	229 aa 24.6 kDa	No	4
SYNGR3-003 ENSP00000455344 ENST00000563869	H3BPJ5 [Direct mapping] Synaptogyrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	240 aa 25.9 kDa	No	0
SYNGR3-004 ENSP00000454756 ENST00000568896	H3BNA6 [Direct mapping] Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	178 aa 19.4 kDa	No	2
SYNGR3-005 ENSP00000455577 ENST00000562045	H3BQ28 [Direct mapping] Synaptogyrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	76 aa 7.8 kDa	No	0
SYNGR3-201 ENSP00000481324 ENST00000618464	Q96L30 [Direct mapping] SYNGR3 protein; Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	145 aa 15.2 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.