Tissue expression of SYNGR3 - Summary - The Human Protein Atlas

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SYNGR3

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SYNGR3
Gene description	Synaptogyrin 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (hypothalamus, cerebral cortex, cerebellum, hippocampus, caudate)
FANTOM5:	Group enriched (brain, hippocampus, caudate, cerebellum, placenta)

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in the CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA042842 , CAB034278
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hypothalamus, cerebral cortex, cerebellum, hippocampus, caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, hippocampus, caudate, cerebellum, placenta)

GENE INFORMATION
Gene name	SYNGR3
Synonyms
Description	Synaptogyrin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1989660 - 1994275
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127561 (version 83.38)
Entrez gene	9143
UniProt	O43761 (UniProt - Evidence at protein level)
neXtProt	NX_O43761
Antibodypedia	SYNGR3 antibodies

PROTEIN BROWSER

SYNGR3-001	SYNGR3-003	SYNGR3-004	SYNGR3-005	SYNGR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNGR3-001 ENSP00000248121 ENST00000248121	O43761 [Direct mapping] Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008021 [synaptic vesicle] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] GO:0032411 [positive regulation of transporter activity] GO:0042169 [SH2 domain binding] GO:0045202 [synapse] GO:0047485 [protein N-terminus binding] Show all	229 aa 24.6 kDa	No	4
SYNGR3-003 ENSP00000455344 ENST00000563869	H3BPJ5 [Direct mapping] Synaptogyrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	240 aa 25.9 kDa	No	0
SYNGR3-004 ENSP00000454756 ENST00000568896	H3BNA6 [Direct mapping] Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	178 aa 19.4 kDa	No	2
SYNGR3-005 ENSP00000455577 ENST00000562045	H3BQ28 [Direct mapping] Synaptogyrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	76 aa 7.8 kDa	No	0
SYNGR3-201 ENSP00000481324 ENST00000618464	Q96L30 [Direct mapping] SYNGR3 protein; Synaptogyrin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030672 [synaptic vesicle membrane] GO:0031594 [neuromuscular junction] Show all	145 aa 15.2 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.