Cell atlas - AAMP - The Human Protein Atlas

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AAMP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubules

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	AAMP
Gene description	Angio-associated, migratory cell protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported)
Additional location	In addition localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Microtubules in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB017717 , HPA031868
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the cytosol.

Main location

Microtubules (supported)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
CAB017717	A-431	Microtubules
CAB017717	A-431	Cytosol
CAB017717	U-2 OS	Microtubules
CAB017717	U-251 MG	Microtubules
HPA031868	A-431	Microtubules
HPA031868	A-431	Cytosol
HPA031868	MCF7	Cytokinetic bridge	Intensity	Intensity
HPA031868	U-2 OS	Microtubules
HPA031868	U-2 OS	Cytosol

MOUSE CELLS

Main location

Microtubules

Additional location

Cytosol

Mouse gene

ENSMUSG00000006299 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA031868	NIH 3T3	Microtubules
	HPA031868	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	AAMP
Synonyms
Description	Angio-associated, migratory cell protein (HGNC Symbol)
Entrez gene summary	The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218264123 - 218270257
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127837 (version 83.38)
Entrez gene	14
UniProt	Q13685 (UniProt - Evidence at protein level)
neXtProt	NX_Q13685
Antibodypedia	AAMP antibodies

PROTEIN BROWSER

AAMP-001	AAMP-002	AAMP-005	AAMP-007	AAMP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AAMP-001 ENSP00000248450 ENST00000248450	Q13685 [Direct mapping] Angio-associated migratory cell protein A0A024R410 [Target identity:100%; Query identity:100%] Angio-associated, migratory cell protein, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0014909 [smooth muscle cell migration] GO:0030154 [cell differentiation] Show all	434 aa 46.8 kDa	No	0
AAMP-002 ENSP00000403343 ENST00000444053	C9JEH3 [Direct mapping] Angio-associated migratory cell protein; Angio-associated, migratory cell protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	435 aa 46.8 kDa	No	0
AAMP-005 ENSP00000416394 ENST00000420660	C9JG97 [Direct mapping] Angio-associated migratory cell protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	415 aa 44.7 kDa	No	0
AAMP-007 ENSP00000393818 ENST00000447885	C9JTS3 [Direct mapping] Angio-associated migratory cell protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	201 aa 22 kDa	No	0
AAMP-009 ENSP00000396295 ENST00000422731	H7C0R2 [Direct mapping] Angio-associated migratory cell protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	189 aa 20 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.