Expression of ECHS1 in cancer - Summary

CANCER ATLAS

Gene description

Enoyl CoA hydratase, short chain, 1, mitochondrial

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA021995	HPA022476	CAB003783

GENE INFORMATION
Gene name	ECHS1 (HGNC Symbol)
Synonyms	SCEH
Description	Enoyl CoA hydratase, short chain, 1, mitochondrial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	133362480 - 133373689
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127884 (version 83.38)
Entrez gene	1892
UniProt	P30084 (UniProt - Evidence at protein level)
neXtProt	NX_P30084
Antibodypedia	ECHS1 antibodies

PROTEIN BROWSER

ECHS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECHS1-001 ENSP00000357535 ENST00000368547	P30084 [Direct mapping] Enoyl-CoA hydratase, mitochondrial Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004300 [enoyl-CoA hydratase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	290 aa 31.4 kDa	No	0