Expression of CDC42EP1 in cancer - Summary

CANCER ATLAS

Gene description

CDC42 effector protein (Rho GTPase binding) 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006379

GENE INFORMATION
Gene name	CDC42EP1 (HGNC Symbol)
Synonyms	Borg5, CEP1, MSE55
Description	CDC42 effector protein (Rho GTPase binding) 1 (HGNC Symbol)
Entrez gene summary	CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37560447 - 37569405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128283 (version 83.38)
Entrez gene	11135
UniProt	Q00587 (UniProt - Evidence at protein level)
neXtProt	NX_Q00587
Antibodypedia	CDC42EP1 antibodies

PROTEIN BROWSER

CDC42EP1-001	CDC42EP1-002	CDC42EP1-003	CDC42EP1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC42EP1-001 ENSP00000249014 ENST00000249014	Q00587 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007266 [Rho protein signal transduction] GO:0008360 [regulation of cell shape] GO:0015629 [actin cytoskeleton] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0031274 [positive regulation of pseudopodium assembly] GO:0043547 [positive regulation of GTPase activity] Show all	391 aa 40.3 kDa	No	0
CDC42EP1-002 ENSP00000411682 ENST00000430687	B0QYC8 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	70 aa 7.3 kDa	No	0
CDC42EP1-003 ENSP00000403710 ENST00000434728	B0QYC6 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	48 aa 5 kDa	No	0
CDC42EP1-004 ENSP00000405006 ENST00000415670	B0QYC7 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	60 aa 6.3 kDa	No	0