Cell atlas - CDC42EP1 - The Human Protein Atlas

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CDC42EP1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Plasma membrane

Human cell
	Actin Filaments
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CDC42EP1
Gene description	CDC42 effector protein (Rho GTPase binding) 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & actin filaments.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Actin filaments (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006379
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & actin filaments.

Main location

Plasma membrane (approved), Actin filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006379	A-431	Plasma membrane
	HPA006379	A-431	Actin filaments
	HPA006379	U-2 OS	Plasma membrane
	HPA006379	U-251 MG	Plasma membrane
	HPA006379	U-251 MG	Actin filaments

GENE INFORMATION
Gene name	CDC42EP1 (HGNC Symbol)
Synonyms	Borg5, CEP1, MSE55
Description	CDC42 effector protein (Rho GTPase binding) 1 (HGNC Symbol)
Entrez gene summary	CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37560447 - 37569405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128283 (version 83.38)
Entrez gene	11135
UniProt	Q00587 (UniProt - Evidence at protein level)
neXtProt	NX_Q00587
Antibodypedia	CDC42EP1 antibodies

PROTEIN BROWSER

CDC42EP1-001	CDC42EP1-002	CDC42EP1-003	CDC42EP1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC42EP1-001 ENSP00000249014 ENST00000249014	Q00587 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007266 [Rho protein signal transduction] GO:0008360 [regulation of cell shape] GO:0015629 [actin cytoskeleton] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0031274 [positive regulation of pseudopodium assembly] GO:0043547 [positive regulation of GTPase activity] Show all	391 aa 40.3 kDa	No	0
CDC42EP1-002 ENSP00000411682 ENST00000430687	B0QYC8 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	70 aa 7.3 kDa	No	0
CDC42EP1-003 ENSP00000403710 ENST00000434728	B0QYC6 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	48 aa 5 kDa	No	0
CDC42EP1-004 ENSP00000405006 ENST00000415670	B0QYC7 [Direct mapping] Cdc42 effector protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0043547 [positive regulation of GTPase activity] Show all	60 aa 6.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.