Expression of SPECC1 in cancer - Summary

CANCER ATLAS

Gene description

Sperm antigen with calponin homology and coiled-coil domains 1

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA021421	HPA021430

GENE INFORMATION
Gene name	SPECC1 (HGNC Symbol)
Synonyms	CYTSB, FLJ36955, HCMOGT-1, NSP
Description	Sperm antigen with calponin homology and coiled-coil domains 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	20009344 - 20319026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128487 (version 83.38)
Entrez gene	92521
UniProt	Q5M775 (UniProt - Evidence at protein level)
neXtProt	NX_Q5M775
Antibodypedia	SPECC1 antibodies

PROTEIN BROWSER

SPECC1-001	SPECC1-002	SPECC1-003	SPECC1-004	SPECC1-014	SPECC1-015	SPECC1-016	SPECC1-017	SPECC1-018	SPECC1-020	SPECC1-021	SPECC1-024	SPECC1-025	SPECC1-026	SPECC1-027	SPECC1-028	SPECC1-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPECC1-001 ENSP00000462471 ENST00000581399	J3KSG2 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	534 aa 60 kDa	No	0
SPECC1-002 ENSP00000378900 ENST00000395529	Q5M775 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	790 aa 87.9 kDa	No	0
SPECC1-003 ENSP00000378893 ENST00000395522	Q5M775 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	703 aa 79 kDa	No	0
SPECC1-004 ENSP00000378901 ENST00000395530	Q5M775 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	987 aa 110.2 kDa	No	0
SPECC1-014 ENSP00000462266 ENST00000578321	J3KS18 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2 kDa	No	0
SPECC1-015 ENSP00000464639 ENST00000582604	J3QSD6 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.2 kDa	No	0
SPECC1-016 ENSP00000464341 ENST00000581973	J3QRQ9 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		102 aa 10.6 kDa	No	0
SPECC1-017 ENSP00000461944 ENST00000580934	J3KRD8 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.6 kDa	No	0
SPECC1-018 ENSP00000261503 ENST00000261503	Q5M775 [Direct mapping] Cytospin-B A0A024QYY9 [Target identity:100%; Query identity:100%] Spectrin domain with coiled-coils 1, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	1068 aa 118.6 kDa	No	0
SPECC1-020 ENSP00000464489 ENST00000583463	J3QS22 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		133 aa 14 kDa	No	0
SPECC1-021 ENSP00000462987 ENST00000578153	J3KTH6 [Direct mapping] Cytospin-B Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.1 kDa	No	0
SPECC1-024 ENSP00000461918 ENST00000583528	J3KRB9 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.1 kDa	No	0
SPECC1-025 ENSP00000463006 ENST00000583482	J3KTI9 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		101 aa 10.5 kDa	No	0
SPECC1-026 ENSP00000378896 ENST00000395525	Q5M775 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	709 aa 79.5 kDa	No	0
SPECC1-027 ENSP00000378898 ENST00000395527	Q5M775 [Direct mapping] Cytospin-B A0A024QYY9 [Target identity:100%; Query identity:100%] Spectrin domain with coiled-coils 1, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	1068 aa 118.6 kDa	No	0
SPECC1-028 ENSP00000463799 ENST00000584527	J3QQM0 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		202 aa 23.4 kDa	No	0
SPECC1-029 ENSP00000462092 ENST00000582226	J3KRN9 [Direct mapping] Cytospin-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		167 aa 18.9 kDa	No	0