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FOXP2

GENERAL INFORMATION

Gene name

 FOXP2

Gene description

 Forkhead box P2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 18
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000382 , HPA000383
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 FOXP2 (HGNC Symbol)

Synonyms

 CAGH44, SPCH1, TNRC10

Description

 Forkhead box P2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Chromosome

 7

Cytoband

 q31.1

Chromosome location (bp)

 114086327 - 114693772

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128573 (version 83.38)

Entrez gene

 93986

UniProt

 O15409 (UniProt - Evidence at protein level)

neXtProt

 NX_O15409

Antibodypedia

 FOXP2 antibodies

PROTEIN BROWSER
«
FOXP2-001
FOXP2-004
FOXP2-005
FOXP2-007
FOXP2-010
FOXP2-014
FOXP2-015
FOXP2-016
FOXP2-017
FOXP2-018
FOXP2-020
FOXP2-021
FOXP2-022
FOXP2-023
FOXP2-025
FOXP2-027
FOXP2-201
FOXP2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXP2-001
ENSP00000265436
ENST00000350908
O15409 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 715 aa
79.9 kDa 		No 0
FOXP2-004
ENSP00000386200
ENST00000408937
O15409 [Direct mapping]
Forkhead box protein P2
X5D2H2 [Target identity:100%; Query identity:100%]
Forkhead box P2 isoform B; Forkhead box P2, isoform CRA_e
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007519 [skeletal muscle tissue development]
GO:0009791 [post-embryonic development]
GO:0021549 [cerebellum development]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0030324 [lung development]
GO:0040007 [growth]
GO:0042297 [vocal learning]
GO:0042803 [protein homodimerization activity]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048286 [lung alveolus development]
GO:0048745 [smooth muscle tissue development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060013 [righting reflex]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
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 740 aa
82.6 kDa 		No 0
FOXP2-005
ENSP00000377135
ENST00000393498
A8MUV4 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 694 aa
77.2 kDa 		No 0
FOXP2-007
ENSP00000418100
ENST00000462331
Q75MZ5 [Direct mapping]
Forkhead box P2, isoform CRA_a; Forkhead box protein P2; Putative uncharacterized protein FOXP2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 67 aa
7.2 kDa 		No 0
FOXP2-010
ENSP00000367482
ENST00000378237
O15409 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 365 aa
41 kDa 		No 0
FOXP2-014
ENSP00000377132
ENST00000393494
O15409 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 715 aa
79.9 kDa 		No 0
FOXP2-015
ENSP00000409826
ENST00000452963
C9JQP8 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 205 aa
23.7 kDa 		No 0
FOXP2-016
ENSP00000375084
ENST00000390668
Q8N6B5 [Direct mapping]
Forkhead box P2, isoform CRA_d; Forkhead box protein P2; Forkhead/winged helix transcription factor
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 456 aa
51.3 kDa 		No 0
FOXP2-017
ENSP00000353367
ENST00000360232
O15409 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 432 aa
48.8 kDa 		No 0
FOXP2-018
ENSP00000377133
ENST00000393495
A8MTU2 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 171 aa
18.5 kDa 		No 0
FOXP2-020
ENSP00000377129
ENST00000393489
O15409 [Direct mapping]
Forkhead box protein P2
A0A024R752 [Target identity:100%; Query identity:100%]
Forkhead box P2, isoform CRA_f
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 623 aa
70.1 kDa 		No 0
FOXP2-021
ENSP00000489229
ENST00000635534
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 712 aa
79.3 kDa 		No 0
FOXP2-022
ENSP00000489135
ENST00000634411
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 698 aa
77.7 kDa 		No 0
FOXP2-023
ENSP00000488944
ENST00000634623
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 590 aa
66.2 kDa 		No 0
FOXP2-025
ENSP00000488954
ENST00000635563
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 229 aa
25.6 kDa 		No 0
FOXP2-027
ENSP00000489073
ENST00000635638
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 716 aa
80 kDa 		No 0
FOXP2-201
ENSP00000377130
ENST00000393491
Q0PRL4 [Direct mapping]
Forkhead box P2 variant 3; Forkhead box protein P2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 530 aa
59.9 kDa 		No 0
FOXP2-202
ENSP00000385069
ENST00000403559
O15409 [Direct mapping]
Forkhead box protein P2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021757 [caudate nucleus development]
GO:0021758 [putamen development]
GO:0021987 [cerebral cortex development]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 732 aa
81.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.