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FLNC

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GENERAL INFORMATION

Gene name

 FLNC

Gene description

 Filamin C, gamma

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enhanced (BJ, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA006135
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006135 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 FLNC (HGNC Symbol)

Synonyms

 ABP-280, ABPL, FLN2

Description

 Filamin C, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q32.1

Chromosome location (bp)

 128830377 - 128859274

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128591 (version 83.38)

Entrez gene

 2318

UniProt

 Q14315 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14315

Antibodypedia

 FLNC antibodies

PROTEIN BROWSER
FLNC-001
FLNC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLNC-001
ENSP00000327145
ENST00000325888
Q14315 [Direct mapping]
Filamin-C
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0016528 [sarcoplasm]
GO:0030018 [Z disc]
GO:0030506 [ankyrin binding]
GO:0034329 [cell junction assembly]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0048747 [muscle fiber development]
Show all
 2725 aa
291 kDa 		No 0
FLNC-002
ENSP00000344002
ENST00000346177
Q14315 [Direct mapping]
Filamin-C
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0030018 [Z disc]
GO:0030506 [ankyrin binding]
GO:0034329 [cell junction assembly]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
Show all
 2692 aa
287.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.