Fields »
ABOUT
HELP
BLOG
IRF5

CANCER ATLAS

Gene description

 Interferon regulatory factor 5

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA046700

GENE INFORMATION

Gene name

 IRF5

Synonyms

Description

 Interferon regulatory factor 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]

Chromosome

 7

Cytoband

 q32.1

Chromosome location (bp)

 128937612 - 128950035

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128604 (version 83.38)

Entrez gene

 3663

UniProt

 Q13568 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13568

Antibodypedia

 IRF5 antibodies

PROTEIN BROWSER
«
IRF5-001
IRF5-002
IRF5-003
IRF5-005
IRF5-008
IRF5-009
IRF5-010
IRF5-011
IRF5-201
IRF5-202
IRF5-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRF5-001
ENSP00000385352
ENST00000402030
Q13568 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 498 aa
56 kDa 		No 0
IRF5-002
ENSP00000349770
ENST00000357234
Q13568 [Direct mapping]
Interferon regulatory factor 5
A0A024R763 [Target identity:100%; Query identity:100%]
Interferon regulatory factor 5, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 514 aa
57.8 kDa 		No 0
IRF5-003
ENSP00000418037
ENST00000489702
C9JAU6 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0051607 [defense response to virus]
Show all
 152 aa
17.2 kDa 		No 0
IRF5-005
ENSP00000419950
ENST00000477535
Q13568 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 412 aa
47 kDa 		No 0
IRF5-008
ENSP00000417770
ENST00000479582
C9J7M2 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0051607 [defense response to virus]
Show all
 141 aa
15.9 kDa 		No 0
IRF5-009
ENSP00000419149
ENST00000473745
Q13568 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 498 aa
56 kDa 		No 0
IRF5-010
ENSP00000419056
ENST00000464557
C9JYP7 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0051607 [defense response to virus]
Show all
 106 aa
12.1 kDa 		No 0
IRF5-011
ENSP00000417454
ENST00000467002
C9JB67 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0051607 [defense response to virus]
Show all
 59 aa
6.7 kDa 		No 0
IRF5-201
ENSP00000249375
ENST00000249375
Q13568 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 498 aa
56 kDa 		No 0
IRF5-202
ENSP00000480058
ENST00000613821
A0A087WWA0 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0051607 [defense response to virus]
Show all
 157 aa
17.8 kDa 		No 0
IRF5-203
ENSP00000483292
ENST00000619830
Q13568 [Direct mapping]
Interferon regulatory factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0043065 [positive regulation of apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
Show all
 147 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.