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This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019221 [cytokine-mediated signaling pathway] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032735 [positive regulation of interleukin-12 production] GO:0043065 [positive regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019221 [cytokine-mediated signaling pathway] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032735 [positive regulation of interleukin-12 production] GO:0043065 [positive regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0019221 [cytokine-mediated signaling pathway] GO:0051607 [defense response to virus]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019221 [cytokine-mediated signaling pathway] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032735 [positive regulation of interleukin-12 production] GO:0043065 [positive regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0019221 [cytokine-mediated signaling pathway] GO:0051607 [defense response to virus]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019221 [cytokine-mediated signaling pathway] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032735 [positive regulation of interleukin-12 production] GO:0043065 [positive regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0019221 [cytokine-mediated signaling pathway] GO:0051607 [defense response to virus]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0019221 [cytokine-mediated signaling pathway] GO:0051607 [defense response to virus]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019221 [cytokine-mediated signaling pathway] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032735 [positive regulation of interleukin-12 production] GO:0043065 [positive regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0019221 [cytokine-mediated signaling pathway] GO:0051607 [defense response to virus]