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ARHGAP22

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GENERAL INFORMATION

Gene name

 ARHGAP22

Gene description

 Rho GTPase activating protein 22

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.

RNA cell category

 Cell line enhanced (U-87 MG, TIME, LHCN-M2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB020696
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, TIME, LHCN-M2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.

Main location

 Nucleoplasm (supported), Cytosol (supported)

Additional location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB020696 A-431 Nucleoplasm
Cytosol
CAB020696 U-2 OS Nucleoplasm
Plasma membrane
CAB020696 U-251 MG Nucleoplasm
Nuclear bodies
Cytosol

GENE INFORMATION

Gene name

 ARHGAP22 (HGNC Symbol)

Synonyms

 RhoGAP2

Description

 Rho GTPase activating protein 22 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

Chromosome location (bp)

 48446034 - 48656265

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128805 (version 83.38)

Entrez gene

 58504

UniProt

 Q7Z5H3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z5H3

Antibodypedia

 ARHGAP22 antibodies

PROTEIN BROWSER
ARHGAP22-001
ARHGAP22-002
ARHGAP22-003
ARHGAP22-004
ARHGAP22-005
ARHGAP22-006
ARHGAP22-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP22-001
ENSP00000249601
ENST00000249601
Q7Z5H3 [Direct mapping]
Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 698 aa
76.8 kDa 		No 0
ARHGAP22-002
ENSP00000412461
ENST00000417912
Q7Z5H3 [Direct mapping]
Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 714 aa
78.5 kDa 		No 0
ARHGAP22-003
ENSP00000410054
ENST00000417247
Q7Z5H3 [Direct mapping]
Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 608 aa
66.6 kDa 		No 0
ARHGAP22-004
ENSP00000416701
ENST00000435790
Q7Z5H3 [Direct mapping]
Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 704 aa
77.5 kDa 		No 0
ARHGAP22-005
ENSP00000363287
ENST00000374172
A6NHM7 [Direct mapping]
Rho GTPase activating protein 22, isoform CRA_a; Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 589 aa
64.3 kDa 		No 0
ARHGAP22-006
ENSP00000363285
ENST00000374170
A6NJ38 [Direct mapping]
Rho GTPase-activating protein 22
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 539 aa
58.6 kDa 		No 0
ARHGAP22-007
ENSP00000422868
ENST00000477708
D6R9V6 [Direct mapping]
Rho GTPase-activating protein 22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 531 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.