Expression of LOXL1 in cancer - Summary

CANCER ATLAS

Gene description

Lysyl oxidase-like 1

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042111

GENE INFORMATION
Gene name	LOXL1 (HGNC Symbol)
Synonyms	LOL, LOXL
Description	Lysyl oxidase-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	73925989 - 73952137
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129038 (version 83.38)
Entrez gene	4016
UniProt	Q08397 (UniProt - Evidence at protein level)
neXtProt	NX_Q08397
Antibodypedia	LOXL1 antibodies

PROTEIN BROWSER

LOXL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LOXL1-001 ENSP00000261921 ENST00000261921	Q08397 [Direct mapping] Lysyl oxidase homolog 1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0005507 [copper ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0018277 [protein deamination] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0032496 [response to lipopolysaccharide] GO:0035904 [aorta development] GO:0055114 [oxidation-reduction process] Show all	574 aa 63.1 kDa	Yes	0