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LOXL1

GENERAL INFORMATION

Gene name

 LOXL1

Gene description

 Lysyl oxidase-like 1

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular matrix and plasma positivity in several tissues with additional cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA042111
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 LOXL1 (HGNC Symbol)

Synonyms

 LOL, LOXL

Description

 Lysyl oxidase-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q24.1

Chromosome location (bp)

 73925989 - 73952137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129038 (version 83.38)

Entrez gene

 4016

UniProt

 Q08397 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08397

Antibodypedia

 LOXL1 antibodies

PROTEIN BROWSER
LOXL1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LOXL1-001
ENSP00000261921
ENST00000261921
Q08397 [Direct mapping]
Lysyl oxidase homolog 1
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001669 [acrosomal vesicle]
GO:0005507 [copper ion binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor]
GO:0018277 [protein deamination]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032496 [response to lipopolysaccharide]
GO:0035904 [aorta development]
GO:0055114 [oxidation-reduction process]
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 574 aa
63.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.