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MBD4

CANCER ATLAS

Gene description

 Methyl-CpG binding domain 4 DNA glycosylase

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002031

GENE INFORMATION

Gene name

 MBD4 (HGNC Symbol)

Synonyms

 MED1

Description

 Methyl-CpG binding domain 4 DNA glycosylase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 129430944 - 129440179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129071 (version 83.38)

Entrez gene

 8930

UniProt

 O95243 (UniProt - Evidence at protein level)

neXtProt

 NX_O95243

Antibodypedia

 MBD4 antibodies

PROTEIN BROWSER
MBD4-001
MBD4-002
MBD4-003
MBD4-009
MBD4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBD4-001
ENSP00000249910
ENST00000249910
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0032355 [response to estradiol]
GO:0045008 [depyrimidination]
Show all
 580 aa
66.1 kDa 		No 0
MBD4-002
ENSP00000424873
ENST00000503197
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 540 aa
60.9 kDa 		No 0
MBD4-003
ENSP00000394080
ENST00000429544
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 574 aa
65.3 kDa 		No 0
MBD4-009
ENSP00000422327
ENST00000507208
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 572 aa
64.8 kDa 		No 0
MBD4-201
ENSP00000376959
ENST00000393278
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 262 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.