Cell atlas - PALLD - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PALLD
Gene description	Palladin, cytoskeletal associated protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & actin filaments. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (LHCN-M2, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Actin filaments (supported)
Additional location	In addition localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA035905
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & actin filaments. In addition localized to the cytosol.

Main location

Plasma membrane (approved), Actin filaments (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA035905	U-2 OS	Plasma membrane	Intensity	Intensity
		Actin filaments	Intensity	Intensity
		Cytosol	Intensity	Intensity
HPA035905	U-251 MG	Plasma membrane
		Actin filaments	Intensity
		Cytosol	Intensity

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA035905	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. PALLD is mostly expressed during G1, and during Mitosis.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Actin filaments, Cytosol, Plasma membrane

GENE INFORMATION
Gene name	PALLD (HGNC Symbol)
Synonyms	CGI-151, KIAA0992, SIH002
Description	Palladin, cytoskeletal associated protein (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	q32.3
Chromosome location (bp)	168497066 - 168928457
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129116 (version 83.38)
Entrez gene	23022
UniProt	Q8WX93 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WX93
Antibodypedia	PALLD antibodies

PROTEIN BROWSER

PALLD-001	PALLD-002	PALLD-003	PALLD-004	PALLD-005	PALLD-007	PALLD-008	PALLD-009	PALLD-010	PALLD-011	PALLD-012	PALLD-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PALLD-001 ENSP00000261509 ENST00000261509	Q8WX93 [Direct mapping] Palladin B2RTX2 [Target identity:100%; Query identity:100%] Palladin, cytoskeletal associated protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007010 [cytoskeleton organization] GO:0015629 [actin cytoskeleton] GO:0030018 [Z disc] GO:0030027 [lamellipodium] GO:0051371 [muscle alpha-actinin binding] Show all	1106 aa 122 kDa	No	0
PALLD-002 ENSP00000425556 ENST00000505667	Q8WX93 [Direct mapping] Palladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003334 [keratinocyte development] GO:0003382 [epithelial cell morphogenesis] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007010 [cytoskeleton organization] GO:0015629 [actin cytoskeleton] GO:0030018 [Z disc] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0051371 [muscle alpha-actinin binding] Show all	1123 aa 123.7 kDa	No	0
PALLD-003 ENSP00000423063 ENST00000508898	H0Y952 [Direct mapping] Palladin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	512 aa 56.5 kDa	No	0
PALLD-004 ENSP00000426947 ENST00000512127	Q8WX93 [Direct mapping] Palladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007010 [cytoskeleton organization] GO:0015629 [actin cytoskeleton] GO:0030018 [Z disc] GO:0030027 [lamellipodium] GO:0051371 [muscle alpha-actinin binding] Show all	777 aa 85.9 kDa	No	0
PALLD-005 ENSP00000424016 ENST00000507735	Q8WX93 [Direct mapping] Palladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007010 [cytoskeleton organization] GO:0015629 [actin cytoskeleton] GO:0030018 [Z disc] GO:0030027 [lamellipodium] GO:0051371 [muscle alpha-actinin binding] Show all	672 aa 73.3 kDa	No	0
PALLD-007 ENSP00000423640 ENST00000511948	D6R948 [Direct mapping] Palladin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.2 kDa	No	0
PALLD-008 ENSP00000424121 ENST00000504519	D6RBH5 [Direct mapping] Palladin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	83 aa 8.9 kDa	No	0
PALLD-009 ENSP00000422016 ENST00000513245	D6R9Z5 [Direct mapping] Palladin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.5 kDa	No	0
PALLD-010 ENSP00000424288 ENST00000503457	D6RBB1 [Direct mapping] Palladin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	96 aa 10.3 kDa	No	0
PALLD-011 ENSP00000422135 ENST00000510998	D6R9F5 [Direct mapping] Palladin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.4 kDa	No	0
PALLD-012 ENSP00000377327 ENST00000393726	F8WA26 [Direct mapping] Palladin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	164 aa 18.5 kDa	No	0
PALLD-013 ENSP00000425729 ENST00000503290	H0YA05 [Direct mapping] Palladin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	160 aa 17.5 kDa	No	0