Fields »
ABOUT
HELP
BLOG
SOX15

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 SOX15

Gene description

 SRY (sex determining region Y)-box 15

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli, the Golgi apparatus & vesicles.

RNA cell category

 Group enriched (HaCaT, A-431, hTCEpi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Additional location

 In addition localized to the Nucleoli (approved), Golgi apparatus (approved), Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA067196 , HPA074049
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, A-431, hTCEpi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli, the Golgi apparatus & vesicles.

Main location

 Nucleus (validated)

Additional location

 Nucleoli (approved), Golgi apparatus (approved), Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA067196 A-431 Nucleus
Vesicles
HPA067196 HaCaT Nucleus
HPA067196 U-2 OS Nucleus
Nucleoli
Vesicles
HPA074049 A-431 Nucleoplasm Intensity
HPA074049 HaCaT Nucleoplasm Intensity
Golgi apparatus
HPA074049 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 SOX15 (HGNC Symbol)

Synonyms

 SOX20, SOX26, SOX27

Description

 SRY (sex determining region Y)-box 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7588178 - 7590170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129194 (version 83.38)

Entrez gene

 6665

UniProt

 O60248 (UniProt - Evidence at protein level)

neXtProt

 NX_O60248

Antibodypedia

 SOX15 antibodies

PROTEIN BROWSER
SOX15-001
SOX15-002
SOX15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX15-001
ENSP00000355354
ENST00000250055
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0044798 [nuclear transcription factor complex]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 233 aa
25.3 kDa 		No 0
SOX15-002
ENSP00000439311
ENST00000538513
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 233 aa
25.3 kDa 		No 0
SOX15-003
ENSP00000458286
ENST00000570788
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 178 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.