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SOX15

GENERAL INFORMATION

Gene name

 SOX15

Gene description

 SRY (sex determining region Y)-box 15

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Tissue enhanced (esophagus)
FANTOM5:Group enriched (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and nucleolar expression in a group of tissues, most abundant in squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA067196
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION

Gene name

 SOX15 (HGNC Symbol)

Synonyms

 SOX20, SOX26, SOX27

Description

 SRY (sex determining region Y)-box 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7588178 - 7590170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129194 (version 83.38)

Entrez gene

 6665

UniProt

 O60248 (UniProt - Evidence at protein level)

neXtProt

 NX_O60248

Antibodypedia

 SOX15 antibodies

PROTEIN BROWSER
SOX15-001
SOX15-002
SOX15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX15-001
ENSP00000355354
ENST00000250055
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0044798 [nuclear transcription factor complex]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 233 aa
25.3 kDa 		No 0
SOX15-002
ENSP00000439311
ENST00000538513
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 233 aa
25.3 kDa 		No 0
SOX15-003
ENSP00000458286
ENST00000570788
O60248 [Direct mapping]
Protein SOX-15
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008584 [male gonad development]
GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration]
GO:0030154 [cell differentiation]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048627 [myoblast development]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 178 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.