Cell atlas - MTUS1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MTUS1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Nucleoli

Human cell
	Microtubules
	Nucleoli

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MTUS1
Gene description	Microtubule associated tumor suppressor 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & microtubules.
RNA cell category	Cell line enhanced (HUVEC TERT2, A549, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported), Microtubules (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA067903 , HPA069795
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, A549, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & microtubules.

Main location

Nucleoli (supported), Microtubules (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067903	A549	Microtubules
	HPA067903	SK-MEL-30	Microtubules
	HPA067903	U-2 OS	Nucleoli
	HPA067903	U-2 OS	Microtubules
	HPA069795	A549	Nucleoli	Intensity
	HPA069795	A549	Microtubules	Intensity
	HPA069795	SK-MEL-30	Nucleoli
	HPA069795	SK-MEL-30	Microtubules
	HPA069795	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	MTUS1 (HGNC Symbol)
Synonyms	ATBP, ATIP1, DKFZp586D1519, FLJ14295, ICIS, KIAA1288, MP44, MTSG1
Description	Microtubule associated tumor suppressor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	17643795 - 17800917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129422 (version 83.38)
Entrez gene	57509
UniProt	Q9ULD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULD2
Antibodypedia	MTUS1 antibodies

PROTEIN BROWSER

MTUS1-001	MTUS1-004	MTUS1-005	MTUS1-011	MTUS1-015	MTUS1-028	MTUS1-201	MTUS1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTUS1-001 ENSP00000262102 ENST00000262102	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	1270 aa 141.4 kDa	No	0
MTUS1-004 ENSP00000430167 ENST00000519263	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	1216 aa 135.7 kDa	No	0
MTUS1-005 ENSP00000297488 ENST00000297488	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	436 aa 50.5 kDa	No	0
MTUS1-011 ENSP00000371285 ENST00000381861	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	517 aa 59 kDa	No	1
MTUS1-015 ENSP00000489015 ENST00000519066		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.5 kDa	No	0
MTUS1-028 ENSP00000489288 ENST00000634613		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		342 aa 39.8 kDa	No	0
MTUS1-201 ENSP00000371293 ENST00000381869	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	1216 aa 135.7 kDa	No	0
MTUS1-202 ENSP00000445738 ENST00000544260	Q9ULD2 [Direct mapping] Microtubule-associated tumor suppressor 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0005886 [plasma membrane] Show all	415 aa 48 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.