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KLK8

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GENERAL INFORMATION

Gene name

 KLK8

Gene description

 Kallikrein-related peptidase 8

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Group enriched (CAPAN-2, A-431, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
CAB019393
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (CAPAN-2, A-431, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB019393 A-431 Vesicles

GENE INFORMATION

Gene name

 KLK8 (HGNC Symbol)

Synonyms

 HNP, neuropsin, ovasin, PRSS19, TADG14

Description

 Kallikrein-related peptidase 8 (HGNC Symbol)

Entrez gene summary

 Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 q13.41

Chromosome location (bp)

 50996007 - 51002711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129455 (version 83.38)

Entrez gene

 11202

UniProt

 O60259 (UniProt - Evidence at protein level)

neXtProt

 NX_O60259

Antibodypedia

 KLK8 antibodies

PROTEIN BROWSER
KLK8-001
KLK8-002
KLK8-004
KLK8-007
KLK8-009
KLK8-201
KLK8-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLK8-001
ENSP00000472016
ENST00000600767
O60259 [Direct mapping]
Kallikrein-8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007613 [memory]
GO:0008219 [cell death]
GO:0009611 [response to wounding]
GO:0031642 [negative regulation of myelination]
GO:0043616 [keratinocyte proliferation]
GO:0048681 [negative regulation of axon regeneration]
GO:0048812 [neuron projection morphogenesis]
GO:0050807 [regulation of synapse organization]
Show all
 260 aa
28 kDa 		Yes 0
KLK8-002
ENSP00000375682
ENST00000391806
O60259 [Direct mapping]
Kallikrein-8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007613 [memory]
GO:0008219 [cell death]
GO:0009611 [response to wounding]
GO:0031642 [negative regulation of myelination]
GO:0043616 [keratinocyte proliferation]
GO:0048681 [negative regulation of axon regeneration]
GO:0048812 [neuron projection morphogenesis]
GO:0050807 [regulation of synapse organization]
GO:0050808 [synapse organization]
Show all
 305 aa
33 kDa 		Yes 0
KLK8-004
ENSP00000341555
ENST00000347619
O60259 [Direct mapping]
Kallikrein-8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007613 [memory]
GO:0008219 [cell death]
GO:0009611 [response to wounding]
GO:0031642 [negative regulation of myelination]
GO:0043616 [keratinocyte proliferation]
GO:0048681 [negative regulation of axon regeneration]
GO:0048812 [neuron projection morphogenesis]
GO:0050807 [regulation of synapse organization]
Show all
 119 aa
12.7 kDa 		Yes 0
KLK8-007
ENSP00000469278
ENST00000593490
O60259 [Direct mapping]
Kallikrein-8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007613 [memory]
GO:0008219 [cell death]
GO:0009611 [response to wounding]
GO:0031642 [negative regulation of myelination]
GO:0043616 [keratinocyte proliferation]
GO:0048681 [negative regulation of axon regeneration]
GO:0048812 [neuron projection morphogenesis]
GO:0050807 [regulation of synapse organization]
Show all
 32 aa
3.7 kDa 		Yes 0
KLK8-009
ENSP00000472273
ENST00000595238
M0R231 [Direct mapping]
Kallikrein-8
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 97 aa
10.7 kDa 		Yes 0
KLK8-201
ENSP00000291726
ENST00000291726
A0A0A0MQY9 [Direct mapping]
Kallikrein-8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 139 aa
14.7 kDa 		No 0
KLK8-202
ENSP00000325072
ENST00000320838
O60259 [Direct mapping]
Kallikrein-8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007613 [memory]
GO:0008219 [cell death]
GO:0009611 [response to wounding]
GO:0031642 [negative regulation of myelination]
GO:0043616 [keratinocyte proliferation]
GO:0048681 [negative regulation of axon regeneration]
GO:0048812 [neuron projection morphogenesis]
GO:0050807 [regulation of synapse organization]
Show all
 32 aa
3.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.