Tissue expression of KLK8 - Summary - The Human Protein Atlas

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KLK8

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KLK8
Gene description	Kallikrein-related peptidase 8
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (skin, esophagus, fallopian tube)
GTEx:	Tissue enhanced (esophagus, skin)
FANTOM5:	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in squamous epithelium.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA035761
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skin, esophagus, fallopian tube)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION
Gene name	KLK8 (HGNC Symbol)
Synonyms	HNP, neuropsin, ovasin, PRSS19, TADG14
Description	Kallikrein-related peptidase 8 (HGNC Symbol)
Entrez gene summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	50996007 - 51002711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129455 (version 83.38)
Entrez gene	11202
UniProt	O60259 (UniProt - Evidence at protein level)
neXtProt	NX_O60259
Antibodypedia	KLK8 antibodies

PROTEIN BROWSER

KLK8-001	KLK8-002	KLK8-004	KLK8-007	KLK8-009	KLK8-201	KLK8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK8-001 ENSP00000472016 ENST00000600767	O60259 [Direct mapping] Kallikrein-8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007613 [memory] GO:0008219 [cell death] GO:0009611 [response to wounding] GO:0031642 [negative regulation of myelination] GO:0043616 [keratinocyte proliferation] GO:0048681 [negative regulation of axon regeneration] GO:0048812 [neuron projection morphogenesis] GO:0050807 [regulation of synapse organization] Show all	260 aa 28 kDa	Yes	0
KLK8-002 ENSP00000375682 ENST00000391806	O60259 [Direct mapping] Kallikrein-8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007613 [memory] GO:0008219 [cell death] GO:0009611 [response to wounding] GO:0031642 [negative regulation of myelination] GO:0043616 [keratinocyte proliferation] GO:0048681 [negative regulation of axon regeneration] GO:0048812 [neuron projection morphogenesis] GO:0050807 [regulation of synapse organization] GO:0050808 [synapse organization] Show all	305 aa 33 kDa	Yes	0
KLK8-004 ENSP00000341555 ENST00000347619	O60259 [Direct mapping] Kallikrein-8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007613 [memory] GO:0008219 [cell death] GO:0009611 [response to wounding] GO:0031642 [negative regulation of myelination] GO:0043616 [keratinocyte proliferation] GO:0048681 [negative regulation of axon regeneration] GO:0048812 [neuron projection morphogenesis] GO:0050807 [regulation of synapse organization] Show all	119 aa 12.7 kDa	Yes	0
KLK8-007 ENSP00000469278 ENST00000593490	O60259 [Direct mapping] Kallikrein-8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007613 [memory] GO:0008219 [cell death] GO:0009611 [response to wounding] GO:0031642 [negative regulation of myelination] GO:0043616 [keratinocyte proliferation] GO:0048681 [negative regulation of axon regeneration] GO:0048812 [neuron projection morphogenesis] GO:0050807 [regulation of synapse organization] Show all	32 aa 3.7 kDa	Yes	0
KLK8-009 ENSP00000472273 ENST00000595238	M0R231 [Direct mapping] Kallikrein-8 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	97 aa 10.7 kDa	Yes	0
KLK8-201 ENSP00000291726 ENST00000291726	A0A0A0MQY9 [Direct mapping] Kallikrein-8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	139 aa 14.7 kDa	No	0
KLK8-202 ENSP00000325072 ENST00000320838	O60259 [Direct mapping] Kallikrein-8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007613 [memory] GO:0008219 [cell death] GO:0009611 [response to wounding] GO:0031642 [negative regulation of myelination] GO:0043616 [keratinocyte proliferation] GO:0048681 [negative regulation of axon regeneration] GO:0048812 [neuron projection morphogenesis] GO:0050807 [regulation of synapse organization] Show all	32 aa 3.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.