Cell atlas - NGDN - The Human Protein Atlas

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NGDN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoli
	Nucleus

Human cell
	Mitochondria
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NGDN
Gene description	Neuroguidin, EIF4E binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli & mitochondria. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Mitochondria (approved)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA000944
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli & mitochondria. In addition localized to the nucleus.

Main location

Nucleoli (approved), Mitochondria (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000944	A-431	Nucleus	Spatial
			Nucleoli	Spatial
			Mitochondria	Spatial
	HPA000944	U-2 OS	Nucleus	Spatial
			Nucleoli	Spatial
			Mitochondria	Spatial
	HPA000944	U-251 MG	Nucleus	Spatial
			Nucleoli	Spatial
			Mitochondria	Spatial

GENE INFORMATION
Gene name	NGDN (HGNC Symbol)
Synonyms	C14orf120, DKFZP564O092, LCP5, lpd-2, NGD
Description	Neuroguidin, EIF4E binding protein (HGNC Symbol)
Entrez gene summary	Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23469688 - 23509862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129460 (version 83.38)
Entrez gene	25983
UniProt	Q8NEJ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEJ9
Antibodypedia	NGDN antibodies

PROTEIN BROWSER

NGDN-001	NGDN-002	NGDN-006	NGDN-010	NGDN-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NGDN-001 ENSP00000386134 ENST00000408901	Q8NEJ9 [Direct mapping] Neuroguidin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000775 [chromosome, centromeric region] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0030175 [filopodium] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032040 [small-subunit processome] GO:0044822 [poly(A) RNA binding] Show all	315 aa 35.9 kDa	No	0
NGDN-002 ENSP00000380340 ENST00000397154	Q8NEJ9 [Direct mapping] Neuroguidin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000775 [chromosome, centromeric region] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0030175 [filopodium] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032040 [small-subunit processome] GO:0044822 [poly(A) RNA binding] Show all	311 aa 35.2 kDa	No	0
NGDN-006 ENSP00000451942 ENST00000556699	H0YJQ1 [Direct mapping] Neuroguidin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005730 [nucleolus] GO:0032040 [small-subunit processome] Show all	74 aa 8.5 kDa	No	0
NGDN-010 ENSP00000451779 ENST00000555128	G3V4G1 [Direct mapping] Neuroguidin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005730 [nucleolus] GO:0032040 [small-subunit processome] Show all	142 aa 15.7 kDa	No	0
NGDN-012 ENSP00000450659 ENST00000556483	H0YJ17 [Direct mapping] Neuroguidin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005730 [nucleolus] GO:0032040 [small-subunit processome] Show all	263 aa 29.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.