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Malignant cells displayed a variable staining pattern, with both negative and strongly stained cases within the same tumor type. Strong nuclear staining was observed mainly in breast, ovarian, renal, cervical and endometrial cancers.
Q96IF1 [Direct mapping] LIM domain-containing protein ajuba
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0000932 [cytoplasmic mRNA processing body] GO:0001666 [response to hypoxia] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0030027 [lamellipodium] GO:0030032 [lamellipodium assembly] GO:0030334 [regulation of cell migration] GO:0031328 [positive regulation of cellular biosynthetic process] GO:0031334 [positive regulation of protein complex assembly] GO:0033673 [negative regulation of kinase activity] GO:0033674 [positive regulation of kinase activity] GO:0034613 [cellular protein localization] GO:0035195 [gene silencing by miRNA] GO:0035313 [wound healing, spreading of epidermal cells] GO:0035331 [negative regulation of hippo signaling] GO:0043087 [regulation of GTPase activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406 [positive regulation of MAP kinase activity] GO:0045294 [alpha-catenin binding] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048041 [focal adhesion assembly] GO:0051015 [actin filament binding] GO:1900037 [regulation of cellular response to hypoxia] GO:2000637 [positive regulation of gene silencing by miRNA]