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NRL

GENERAL INFORMATION

Gene name

 NRL

Gene description

 Neural retina leucine zipper

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in rods in retina.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
CAB026066
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 NRL (HGNC Symbol)

Synonyms

 D14S46E, NRL-MAF, RP27

Description

 Neural retina leucine zipper (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

Chromosome location (bp)

 24080107 - 24115014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129535 (version 83.38)

Entrez gene

 4901

UniProt

 P54845 (UniProt - Evidence at protein level)

neXtProt

 NX_P54845

Antibodypedia

 NRL antibodies

PROTEIN BROWSER
NRL-001
NRL-002
NRL-003
NRL-004
NRL-005
NRL-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRL-001
ENSP00000380191
ENST00000396995
P54845 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007468 [regulation of rhodopsin gene expression]
GO:0007601 [visual perception]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0050896 [response to stimulus]
Show all
 98 aa
11.3 kDa 		No 0
NRL-002
ENSP00000380197
ENST00000397002
P54845 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007468 [regulation of rhodopsin gene expression]
GO:0007601 [visual perception]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0050896 [response to stimulus]
Show all
 237 aa
25.9 kDa 		No 0
NRL-003
ENSP00000380193
ENST00000396997
P54845 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007468 [regulation of rhodopsin gene expression]
GO:0007601 [visual perception]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0050896 [response to stimulus]
Show all
 237 aa
25.9 kDa 		No 0
NRL-004
ENSP00000454062
ENST00000561028
P54845 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007468 [regulation of rhodopsin gene expression]
GO:0007601 [visual perception]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045872 [positive regulation of rhodopsin gene expression]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0050896 [response to stimulus]
Show all
 237 aa
25.9 kDa 		No 0
NRL-005
ENSP00000454180
ENST00000558280
H0YNW2 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 65 aa
6.8 kDa 		No 0
NRL-006
ENSP00000452966
ENST00000560550
P54845 [Direct mapping]
Neural retina-specific leucine zipper protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007468 [regulation of rhodopsin gene expression]
GO:0007601 [visual perception]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0050896 [response to stimulus]
Show all
 98 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.