Expression of PLPPR3 in cancer - Summary

CANCER ATLAS

Gene description

Phospholipid phosphatase related 3

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA052293	HPA057034

GENE INFORMATION
Gene name	PLPPR3 (HGNC Symbol)
Synonyms	FLJ11535, LPPR3, PRG-2, PRG2
Description	Phospholipid phosphatase related 3 (HGNC Symbol)
Entrez gene summary	The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	812488 - 821977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129951 (version 83.38)
Entrez gene	79948
UniProt	Q6T4P5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6T4P5
Antibodypedia	PLPPR3 antibodies

PROTEIN BROWSER

PLPPR3-001	PLPPR3-002	PLPPR3-003	PLPPR3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPPR3-001 ENSP00000430297 ENST00000520876	Q6T4P5 [Target identity:100%; Query identity:100%] Lipid phosphate phosphatase-related protein type 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	718 aa 76 kDa	No	6
PLPPR3-002 ENSP00000352962 ENST00000359894		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all		746 aa 78.9 kDa	No	5
PLPPR3-003 ENSP00000466122 ENST00000519502	K7ELK5 [Direct mapping] Lipid phosphate phosphatase-related protein type 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	129 aa 14.2 kDa	No	2
PLPPR3-005 ENSP00000430544 ENST00000517665	H0YBY4 [Direct mapping] Lipid phosphate phosphatase-related protein type 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	120 aa 12.6 kDa	No	1