Tissue expression of PLPPR3 - Summary - The Human Protein Atlas

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PLPPR3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PLPPR3
Gene description	Phospholipid phosphatase related 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, fallopian tube, bone marrow)
GTEx:	Group enriched (hippocampus, hypothalamus, cerebral cortex, caudate, fallopian tube, testis)
FANTOM5:	Group enriched (caudate, hippocampus, brain)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA052293 , HPA057034
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, fallopian tube, bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, hypothalamus, cerebral cortex, caudate, fallopian tube, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, hippocampus, brain)

GENE INFORMATION
Gene name	PLPPR3 (HGNC Symbol)
Synonyms	FLJ11535, LPPR3, PRG-2, PRG2
Description	Phospholipid phosphatase related 3 (HGNC Symbol)
Entrez gene summary	The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	812488 - 821977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129951 (version 83.38)
Entrez gene	79948
UniProt	Q6T4P5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6T4P5
Antibodypedia	PLPPR3 antibodies

PROTEIN BROWSER

PLPPR3-001	PLPPR3-002	PLPPR3-003	PLPPR3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPPR3-001 ENSP00000430297 ENST00000520876	Q6T4P5 [Target identity:100%; Query identity:100%] Lipid phosphate phosphatase-related protein type 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	718 aa 76 kDa	No	6
PLPPR3-002 ENSP00000352962 ENST00000359894		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all		746 aa 78.9 kDa	No	5
PLPPR3-003 ENSP00000466122 ENST00000519502	K7ELK5 [Direct mapping] Lipid phosphate phosphatase-related protein type 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	129 aa 14.2 kDa	No	2
PLPPR3-005 ENSP00000430544 ENST00000517665	H0YBY4 [Direct mapping] Lipid phosphate phosphatase-related protein type 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	120 aa 12.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.