Tissue expression of DOCK6 - Summary - The Human Protein Atlas

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DOCK6

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DOCK6
Gene description	Dedicator of cytokinesis 6
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

General granular cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA049423 , HPA049424
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	DOCK6 (HGNC Symbol)
Synonyms	KIAA1395, ZIR1
Description	Dedicator of cytokinesis 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11199295 - 11262481
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130158 (version 83.38)
Entrez gene	57572
UniProt	Q96HP0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HP0
Antibodypedia	DOCK6 antibodies

PROTEIN BROWSER

DOCK6-001	DOCK6-005	DOCK6-006	DOCK6-012	DOCK6-017	DOCK6-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOCK6-001 ENSP00000294618 ENST00000294618	Q96HP0 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0043547 [positive regulation of GTPase activity] GO:0048471 [perinuclear region of cytoplasm] Show all	2047 aa 229.6 kDa	No	0
DOCK6-005 ENSP00000467191 ENST00000590680	K7EP20 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	464 aa 50.8 kDa	No	0
DOCK6-006 ENSP00000468638 ENST00000587656	K7ESB7 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1336 aa 148.7 kDa	No	0
DOCK6-012 ENSP00000465767 ENST00000585904	K7EKT0 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	185 aa 19.4 kDa	No	0
DOCK6-017 ENSP00000467231 ENST00000588666	K7EP51 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	148 aa 16.7 kDa	No	0
DOCK6-018 ENSP00000468291 ENST00000587734	K7ERK2 [Direct mapping] Dedicator of cytokinesis protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.