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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CNN1
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  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CNN1

Gene description

Calponin 1, basic, smooth muscle

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (smooth muscle, seminal vesicle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Highly selective cytoplasmic expression in smooth muscle and myoepithelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA014263 , CAB000007
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (smooth muscle, seminal vesicle)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin05001,0001,5002,0002,5003,0003,500TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin02004006008001,000RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina01,0002,0003,0004,0005,000Tags Per Million

GENE INFORMATION

Gene name

CNN1 (HGNC Symbol)

Synonyms

Sm-Calp, SMCC

Description

Calponin 1, basic, smooth muscle (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

11538717 - 11550323

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130176 (version 83.38)

Entrez gene

1264

UniProt

P51911 (UniProt - Evidence at protein level)

neXtProt

NX_P51911

Antibodypedia

CNN1 antibodies

PROTEIN BROWSER

CNN1-001
CNN1-002
CNN1-003
CNN1-004
CNN1-005
CNN1-007
CNN1-008
CNN1-009
CNN1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNN1-001
ENSP00000252456
ENST00000252456
P51911 [Direct mapping]
Calponin-1
V9HWA5 [Target identity:100%; Query identity:100%]
Calponin
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006940 [regulation of smooth muscle contraction]
GO:0031032 [actomyosin structure organization]
Show all
297 aa
33.2 kDa
No 0
CNN1-002
ENSP00000468259
ENST00000592923
B7Z7E1 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0031032 [actomyosin structure organization]
Show all
247 aa
27.4 kDa
No 0
CNN1-003
ENSP00000442031
ENST00000535659
B7Z7E1 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0031032 [actomyosin structure organization]
Show all
247 aa
27.4 kDa
No 0
CNN1-004
ENSP00000466886
ENST00000586059
K7ENC5 [Direct mapping]
Calponin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0031032 [actomyosin structure organization]
Show all
116 aa
13.1 kDa
No 0
CNN1-005
ENSP00000468326
ENST00000585869
K7ERM8 [Direct mapping]
Calponin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
120 aa
14.1 kDa
No 0
CNN1-007
ENSP00000468053
ENST00000588935
K7ER02 [Direct mapping]
Calponin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0031032 [actomyosin structure organization]
Show all
228 aa
25 kDa
No 0
CNN1-008
ENSP00000467701
ENST00000586577
K7EQ72 [Direct mapping]
Calponin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0031032 [actomyosin structure organization]
Show all
173 aa
19.1 kDa
No 0
CNN1-009
ENSP00000468737
ENST00000587087
K7ESJ2 [Direct mapping]
Calponin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
115 aa
13 kDa
No 0
CNN1-010
ENSP00000468293
ENST00000592338
K7ERK4 [Direct mapping]
Transgelin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
175 aa
19.4 kDa
No 0

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The Human Protein Atlas project is funded
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