We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Colorectal and renal cancers displayed moderate to strong cytoplasmic and membranous immunoreactivity. Cases of gastric and pancreatic cancers were moderately stained. Remaining cancers were negative.
Renal cancers and a few cases of colorectal and liver cancers showed moderate to strong membranous immunoreactivity. The remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
ACE2
Synonyms
Description
Angiotensin I converting enzyme 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]