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ACE2

GENERAL INFORMATION

Gene name

 ACE2

Gene description

 Angiotensin I converting enzyme 2

Protein class

 Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum, gallbladder, kidney, testis)
GTEx:Group enriched (small intestine, testis)
FANTOM5:Tissue enhanced (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous expression in renal tubules, intestinal tract, gallbladder and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000288 , CAB026174
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum, gallbladder, kidney, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, colon)

GENE INFORMATION

Gene name

 ACE2

Synonyms

Description

 Angiotensin I converting enzyme 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 15561033 - 15602148

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130234 (version 83.38)

Entrez gene

 59272

UniProt

 Q9BYF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYF1

Antibodypedia

 ACE2 antibodies

PROTEIN BROWSER
ACE2-001
ACE2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACE2-001
ENSP00000252519
ENST00000252519
Q9BYF1 [Direct mapping]
Angiotensin-converting enzyme 2 Processed angiotensin-converting enzyme 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001817 [regulation of cytokine production]
GO:0001948 [glycoprotein binding]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032800 [receptor biosynthetic process]
GO:0042127 [regulation of cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046718 [viral entry into host cell]
GO:0046813 [receptor-mediated virion attachment to host cell]
GO:0050727 [regulation of inflammatory response]
GO:0070062 [extracellular exosome]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903779 [regulation of cardiac conduction]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 805 aa
92.5 kDa 		Yes 1
ACE2-201
ENSP00000389326
ENST00000427411
Q9BYF1 [Direct mapping]
Angiotensin-converting enzyme 2 Processed angiotensin-converting enzyme 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001817 [regulation of cytokine production]
GO:0001948 [glycoprotein binding]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0015827 [tryptophan transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032800 [receptor biosynthetic process]
GO:0042127 [regulation of cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046718 [viral entry into host cell]
GO:0046813 [receptor-mediated virion attachment to host cell]
GO:0050727 [regulation of inflammatory response]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903779 [regulation of cardiac conduction]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 805 aa
92.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.