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HBZ

GENERAL INFORMATION

Gene name

 HBZ

Gene description

 Hemoglobin, zeta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, bone marrow, placenta)
GTEx:Tissue enriched (testis)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, bone marrow, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 HBZ (HGNC Symbol)

Synonyms

 HBZ-T1, HBZ1

Description

 Hemoglobin, zeta (HGNC Symbol)

Entrez gene summary

 Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 152687 - 154503

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130656 (version 83.38)

Entrez gene

 3050

UniProt

 P02008 (UniProt - Evidence at protein level)

neXtProt

 NX_P02008

Antibodypedia

 HBZ antibodies

PROTEIN BROWSER
HBZ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBZ-001
ENSP00000252951
ENST00000252951
P02008 [Direct mapping]
Hemoglobin subunit zeta
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0043249 [erythrocyte maturation]
GO:0070062 [extracellular exosome]
Show all
 142 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.