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ADRM1

CANCER ATLAS

Gene description

 Adhesion regulating molecule 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042266

GENE INFORMATION

Gene name

 ADRM1 (HGNC Symbol)

Synonyms

 ARM1, GP110, Rpn13

Description

 Adhesion regulating molecule 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 62302093 - 62308862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130706 (version 83.38)

Entrez gene

 11047

UniProt

 Q16186 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16186

Antibodypedia

 ADRM1 antibodies

PROTEIN BROWSER
ADRM1-001
ADRM1-003
ADRM1-201
ADRM1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRM1-001
ENSP00000478877
ENST00000491935
Q16186 [Direct mapping]
Proteasomal ubiquitin receptor ADRM1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010950 [positive regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0043248 [proteasome assembly]
GO:0061133 [endopeptidase activator activity]
GO:0070628 [proteasome binding]
Show all
 407 aa
42.2 kDa 		No 0
ADRM1-003
ENSP00000479008
ENST00000462554
A0A087WUX6 [Direct mapping]
Proteasomal ubiquitin receptor ADRM1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 141 aa
14.9 kDa 		No 0
ADRM1-201
ENSP00000253003
ENST00000253003
Q16186 [Direct mapping]
Proteasomal ubiquitin receptor ADRM1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010950 [positive regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0043248 [proteasome assembly]
GO:0061133 [endopeptidase activator activity]
GO:0070628 [proteasome binding]
Show all
 407 aa
42.2 kDa 		No 0
ADRM1-202
ENSP00000480756
ENST00000620230
A0A087WX59 [Direct mapping]
Proteasomal ubiquitin receptor ADRM1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 368 aa
37.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.