Tissue expression of ADRM1 - Summary - The Human Protein Atlas

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ADRM1

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADRM1
Gene description	Adhesion regulating molecule 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA042266
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

N/A

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ADRM1 (HGNC Symbol)
Synonyms	ARM1, GP110, Rpn13
Description	Adhesion regulating molecule 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62302093 - 62308862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130706 (version 83.38)
Entrez gene	11047
UniProt	Q16186 (UniProt - Evidence at protein level)
neXtProt	NX_Q16186
Antibodypedia	ADRM1 antibodies

PROTEIN BROWSER

ADRM1-001	ADRM1-003	ADRM1-201	ADRM1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADRM1-001 ENSP00000478877 ENST00000491935	Q16186 [Direct mapping] Proteasomal ubiquitin receptor ADRM1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000502 [proteasome complex] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0010950 [positive regulation of endopeptidase activity] GO:0016020 [membrane] GO:0043248 [proteasome assembly] GO:0061133 [endopeptidase activator activity] GO:0070628 [proteasome binding] Show all	407 aa 42.2 kDa	No	0
ADRM1-003 ENSP00000479008 ENST00000462554	A0A087WUX6 [Direct mapping] Proteasomal ubiquitin receptor ADRM1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] Show all	141 aa 14.9 kDa	No	0
ADRM1-201 ENSP00000253003 ENST00000253003	Q16186 [Direct mapping] Proteasomal ubiquitin receptor ADRM1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000502 [proteasome complex] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0010950 [positive regulation of endopeptidase activity] GO:0016020 [membrane] GO:0043248 [proteasome assembly] GO:0061133 [endopeptidase activator activity] GO:0070628 [proteasome binding] Show all	407 aa 42.2 kDa	No	0
ADRM1-202 ENSP00000480756 ENST00000620230	A0A087WX59 [Direct mapping] Proteasomal ubiquitin receptor ADRM1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] Show all	368 aa 37.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.