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UCK1

CANCER ATLAS

Gene description

 Uridine-cytidine kinase 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050969

GENE INFORMATION

Gene name

 UCK1 (HGNC Symbol)

Synonyms

 FLJ12255, URK1

Description

 Uridine-cytidine kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

Chromosome

 9

Cytoband

 q34.13

Chromosome location (bp)

 131523801 - 131531268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130717 (version 83.38)

Entrez gene

 83549

UniProt

 Q9HA47 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HA47

Antibodypedia

 UCK1 antibodies

PROTEIN BROWSER
UCK1-001
UCK1-002
UCK1-004
UCK1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCK1-001
ENSP00000361289
ENST00000372215
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 277 aa
31.4 kDa 		No 0
UCK1-002
ENSP00000361282
ENST00000372208
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
A0A024R8E7 [Target identity:100%; Query identity:100%]
Uridine-cytidine kinase 1, isoform CRA_e
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 201 aa
22.8 kDa 		No 0
UCK1-004
ENSP00000361285
ENST00000372211
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 282 aa
32.3 kDa 		No 0
UCK1-006
ENSP00000361284
ENST00000372210
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 268 aa
30.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.