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UCK1

GENERAL INFORMATION

Gene name

 UCK1

Gene description

 Uridine-cytidine kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA050969
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UCK1 (HGNC Symbol)

Synonyms

 FLJ12255, URK1

Description

 Uridine-cytidine kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

Chromosome

 9

Cytoband

 q34.13

Chromosome location (bp)

 131523801 - 131531268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130717 (version 83.38)

Entrez gene

 83549

UniProt

 Q9HA47 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HA47

Antibodypedia

 UCK1 antibodies

PROTEIN BROWSER
UCK1-001
UCK1-002
UCK1-004
UCK1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCK1-001
ENSP00000361289
ENST00000372215
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 277 aa
31.4 kDa 		No 0
UCK1-002
ENSP00000361282
ENST00000372208
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
A0A024R8E7 [Target identity:100%; Query identity:100%]
Uridine-cytidine kinase 1, isoform CRA_e
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 201 aa
22.8 kDa 		No 0
UCK1-004
ENSP00000361285
ENST00000372211
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 282 aa
32.3 kDa 		No 0
UCK1-006
ENSP00000361284
ENST00000372210
Q9HA47 [Direct mapping]
Uridine-cytidine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 268 aa
30.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.