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CHMP2A

GENERAL INFORMATION

Gene name

 CHMP2A

Gene description

 Charged multivesicular body protein 2A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041153 , HPA042031
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHMP2A (HGNC Symbol)

Synonyms

 BC-2, CHMP2, VPS2, VPS2A

Description

 Charged multivesicular body protein 2A (HGNC Symbol)

Entrez gene summary

 CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 58551566 - 58555124

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130724 (version 83.38)

Entrez gene

 27243

UniProt

 O43633 (UniProt - Evidence at protein level)

neXtProt

 NX_O43633

Antibodypedia

 CHMP2A antibodies

PROTEIN BROWSER
CHMP2A-001
CHMP2A-003
CHMP2A-004
CHMP2A-006
CHMP2A-007
CHMP2A-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP2A-001
ENSP00000310440
ENST00000312547
O43633 [Direct mapping]
Charged multivesicular body protein 2a
A0A024R4S0 [Target identity:100%; Query identity:100%]
Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010324 [membrane invagination]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0045184 [establishment of protein localization]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0060548 [negative regulation of cell death]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902188 [positive regulation of viral release from host cell]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-003
ENSP00000469240
ENST00000600118
O43633 [Direct mapping]
Charged multivesicular body protein 2a
A0A024R4S0 [Target identity:100%; Query identity:100%]
Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010324 [membrane invagination]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0045184 [establishment of protein localization]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0060548 [negative regulation of cell death]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902188 [positive regulation of viral release from host cell]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-004
ENSP00000472680
ENST00000601220
O43633 [Direct mapping]
Charged multivesicular body protein 2a
A0A024R4S0 [Target identity:100%; Query identity:100%]
Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010324 [membrane invagination]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0045184 [establishment of protein localization]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0060548 [negative regulation of cell death]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902188 [positive regulation of viral release from host cell]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-006
ENSP00000469453
ENST00000597848
M0QXX8 [Direct mapping]
Charged multivesicular body protein 2a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007034 [vacuolar transport]
Show all
 55 aa
6.7 kDa 		No 0
CHMP2A-007
ENSP00000471961
ENST00000596708
M0R1L7 [Direct mapping]
Charged multivesicular body protein 2a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007034 [vacuolar transport]
Show all
 159 aa
18.7 kDa 		No 0
CHMP2A-009
ENSP00000472097
ENST00000600006
M0R1T5 [Direct mapping]
Charged multivesicular body protein 2a
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007034 [vacuolar transport]
Show all
 227 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.