Cell atlas - CLIP1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CLIP1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule ends

Human cell
	Cytosol
	Microtubules

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CLIP1
Gene description	CAP-GLY domain containing linker protein 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & microtubule end.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule ends (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026678
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & microtubule end.

Main location

Microtubule ends (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026678	A-431	Cytosol
	HPA026678	SiHa	Microtubule ends
	HPA026678	U-2 OS	No staining

GENE INFORMATION
Gene name	CLIP1 (HGNC Symbol)
Synonyms	CLIP, CLIP-170, CLIP170, CYLN1, RSN
Description	CAP-GLY domain containing linker protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122271432 - 122422632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130779 (version 83.38)
Entrez gene	6249
UniProt	P30622 (UniProt - Evidence at protein level)
neXtProt	NX_P30622
Antibodypedia	CLIP1 antibodies

PROTEIN BROWSER

CLIP1-001	CLIP1-002	CLIP1-003	CLIP1-005	CLIP1-006	CLIP1-007	CLIP1-008	CLIP1-015	CLIP1-016	CLIP1-017	CLIP1-201	CLIP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLIP1-001 ENSP00000303585 ENST00000302528	P30622 [Direct mapping] CAP-Gly domain-containing linker protein 1 A0A024RBR1 [Target identity:100%; Query identity:100%] Restin (Reed-Steinberg cell-expressed intermediate filament-associated protein), isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0001578 [microtubule bundle formation] GO:0001726 [ruffle] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005882 [intermediate filament] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031116 [positive regulation of microtubule polymerization] GO:0035371 [microtubule plus-end] GO:0042803 [protein homodimerization activity] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0051010 [microtubule plus-end binding] Show all	1427 aa 161 kDa	No	0
CLIP1-002 ENSP00000445531 ENST00000537178	P30622 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0001578 [microtubule bundle formation] GO:0001726 [ruffle] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005882 [intermediate filament] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031116 [positive regulation of microtubule polymerization] GO:0035371 [microtubule plus-end] GO:0042803 [protein homodimerization activity] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0051010 [microtubule plus-end binding] Show all	1392 aa 156.8 kDa	No	0
CLIP1-003 ENSP00000439093 ENST00000540338	P30622 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0001578 [microtubule bundle formation] GO:0001726 [ruffle] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005882 [intermediate filament] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031116 [positive regulation of microtubule polymerization] GO:0035371 [microtubule plus-end] GO:0042803 [protein homodimerization activity] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0051010 [microtubule plus-end binding] Show all	1438 aa 162.2 kDa	No	0
CLIP1-005 ENSP00000437786 ENST00000540304	F5H6A0 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		803 aa 89.6 kDa	No	0
CLIP1-006 ENSP00000441409 ENST00000537004	F6VGP8 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		428 aa 46.2 kDa	No	0
CLIP1-007 ENSP00000355314 ENST00000361654	J3KP58 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0035371 [microtubule plus-end] Show all	1316 aa 148.1 kDa	No	0
CLIP1-008 ENSP00000438743 ENST00000545889	F5H0N7 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0035371 [microtubule plus-end] Show all	1013 aa 116.3 kDa	No	0
CLIP1-015 ENSP00000437617 ENST00000540539	F5H6H4 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	117 aa 13.5 kDa	No	0
CLIP1-016 ENSP00000445387 ENST00000539080	F5H367 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		83 aa 8.9 kDa	No	0
CLIP1-017 ENSP00000439472 ENST00000535290	F5H270 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		108 aa 11.5 kDa	No	0
CLIP1-201 ENSP00000351665 ENST00000358808	P30622 [Direct mapping] CAP-Gly domain-containing linker protein 1 A0A024RBR1 [Target identity:100%; Query identity:100%] Restin (Reed-Steinberg cell-expressed intermediate filament-associated protein), isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0001578 [microtubule bundle formation] GO:0001726 [ruffle] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005882 [intermediate filament] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031116 [positive regulation of microtubule polymerization] GO:0035371 [microtubule plus-end] GO:0042803 [protein homodimerization activity] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0051010 [microtubule plus-end binding] Show all	1427 aa 161 kDa	No	0
CLIP1-202 ENSP00000479322 ENST00000620786	P30622 [Direct mapping] CAP-Gly domain-containing linker protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0001578 [microtubule bundle formation] GO:0001726 [ruffle] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005881 [cytoplasmic microtubule] GO:0005882 [intermediate filament] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031116 [positive regulation of microtubule polymerization] GO:0035371 [microtubule plus-end] GO:0042803 [protein homodimerization activity] GO:0044354 [macropinosome] GO:0044861 [protein transport into plasma membrane raft] GO:0046872 [metal ion binding] GO:0051010 [microtubule plus-end binding] Show all	1438 aa 162.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.