Expression of C12orf65 in cancer - Summary

CANCER ATLAS

Gene description

Chromosome 12 open reading frame 65

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA038194

GENE INFORMATION
Gene name	C12orf65 (HGNC Symbol)
Synonyms	FLJ38663, SPG55
Description	Chromosome 12 open reading frame 65 (HGNC Symbol)
Entrez gene summary	This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123232916 - 123257959
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130921 (version 83.38)
Entrez gene	91574
UniProt	Q9H3J6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H3J6
Antibodypedia	C12orf65 antibodies

PROTEIN BROWSER

C12orf65-001	C12orf65-003	C12orf65-005	C12orf65-006	C12orf65-007	C12orf65-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C12orf65-001 ENSP00000253233 ENST00000253233	Q9H3J6 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003747 [translation release factor activity] GO:0004045 [aminoacyl-tRNA hydrolase activity] GO:0005739 [mitochondrion] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006415 [translational termination] GO:0016150 [translation release factor activity, codon nonspecific] GO:0043022 [ribosome binding] GO:0070126 [mitochondrial translational termination] GO:0072344 [rescue of stalled ribosome] Show all	166 aa 18.8 kDa	No	0
C12orf65-003 ENSP00000444843 ENST00000543139	F5H4X5 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003747 [translation release factor activity] GO:0006415 [translational termination] Show all	138 aa 15.4 kDa	No	0
C12orf65-005 ENSP00000443072 ENST00000536130	F5H5V8 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4 kDa	No	0
C12orf65-006 ENSP00000441796 ENST00000546132	F5GWJ6 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003747 [translation release factor activity] GO:0006415 [translational termination] Show all	96 aa 10.4 kDa	No	0
C12orf65-007 ENSP00000391513 ENST00000429587	Q9H3J6 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003747 [translation release factor activity] GO:0004045 [aminoacyl-tRNA hydrolase activity] GO:0005739 [mitochondrion] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006415 [translational termination] GO:0016150 [translation release factor activity, codon nonspecific] GO:0043022 [ribosome binding] GO:0070126 [mitochondrial translational termination] GO:0072344 [rescue of stalled ribosome] Show all	166 aa 18.8 kDa	No	0
C12orf65-201 ENSP00000390647 ENST00000366329	Q9H3J6 [Direct mapping] Probable peptide chain release factor C12orf65, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003747 [translation release factor activity] GO:0004045 [aminoacyl-tRNA hydrolase activity] GO:0005739 [mitochondrion] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006415 [translational termination] GO:0016150 [translation release factor activity, codon nonspecific] GO:0043022 [ribosome binding] GO:0070126 [mitochondrial translational termination] GO:0072344 [rescue of stalled ribosome] Show all	166 aa 18.8 kDa	No	0