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FBP2

GENERAL INFORMATION

Gene name

 FBP2

Gene description

 Fructose-1,6-bisphosphatase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Group enriched (skeletal muscle, stomach)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA012513
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 FBP2

Synonyms

Description

 Fructose-1,6-bisphosphatase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.32

Chromosome location (bp)

 94558720 - 94593793

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130957 (version 83.38)

Entrez gene

 8789

UniProt

 O00757 (UniProt - Evidence at protein level)

neXtProt

 NX_O00757

Antibodypedia

 FBP2 antibodies

PROTEIN BROWSER
FBP2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBP2-001
ENSP00000364486
ENST00000375337
O00757 [Direct mapping]
Fructose-1,6-bisphosphatase isozyme 2
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0016311 [dephosphorylation]
GO:0030018 [Z disc]
GO:0030054 [cell junction]
GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 339 aa
36.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.