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Weak to moderate cytoplasmic immunoreactivity, often with a granular pattern was observed in most malignancies. Several malignant gliomas, lymphomas, squamous and basal cell carcinomas, stomach, urothelial and pancreatic cancers were negative.
Malignant cells displayed weak to moderate cytoplasmic staining. A few malignant melanomas were strongly stained. Most malignant gliomas were negative.
Most tumors showed weak positivity or were negative. Malignant melanomas displayed moderate to strong cytoplasmic immunoreactivity while for example renal and ovarian cancers showed moderate staining in several cases.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]
Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P36543 [Direct mapping] V-type proton ATPase subunit E 1
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Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P36543 [Direct mapping] V-type proton ATPase subunit E 1
Show all
Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
