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ATP6V1E1

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GENERAL INFORMATION

Gene name

 ATP6V1E1

Gene description

 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA029196
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029196 A-431 Nucleoplasm
HPA029196 U-2 OS Nucleoplasm
HPA029196 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 ATP6V1E1 (HGNC Symbol)

Synonyms

 ATP6E, ATP6E2, ATP6V1E, P31, Vma4

Description

 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 17592136 - 17628818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131100 (version 83.38)

Entrez gene

 529

UniProt

 P36543 (UniProt - Evidence at protein level)

neXtProt

 NX_P36543

Antibodypedia

 ATP6V1E1 antibodies

PROTEIN BROWSER
ATP6V1E1-001
ATP6V1E1-004
ATP6V1E1-005
ATP6V1E1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1E1-001
ENSP00000253413
ENST00000253413
P36543 [Direct mapping]
V-type proton ATPase subunit E 1
Q53Y06 [Target identity:100%; Query identity:100%]
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1, isoform CRA_b; cDNA, FLJ92725, Homo sapiens ATPase, H+ transporting, lysosomal 31kDa, V1 subunit Eisoform 1 (ATP6V1E1), mRNA
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005902 [microvillus]
GO:0006879 [cellular iron ion homeostasis]
GO:0008152 [metabolic process]
GO:0008286 [insulin receptor signaling pathway]
GO:0008553 [hydrogen-exporting ATPase activity, phosphorylative mechanism]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016324 [apical plasma membrane]
GO:0016469 [proton-transporting two-sector ATPase complex]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 226 aa
26.1 kDa 		No 0
ATP6V1E1-004
ENSP00000398932
ENST00000413576
C9J8H1 [Direct mapping]
V-type proton ATPase subunit E 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 203 aa
23.5 kDa 		No 0
ATP6V1E1-005
ENSP00000382696
ENST00000399798
P36543 [Direct mapping]
V-type proton ATPase subunit E 1
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006879 [cellular iron ion homeostasis]
GO:0008152 [metabolic process]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016324 [apical plasma membrane]
GO:0016469 [proton-transporting two-sector ATPase complex]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 204 aa
23.6 kDa 		No 0
ATP6V1E1-006
ENSP00000382694
ENST00000399796
P36543 [Direct mapping]
V-type proton ATPase subunit E 1
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006879 [cellular iron ion homeostasis]
GO:0008152 [metabolic process]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016324 [apical plasma membrane]
GO:0016469 [proton-transporting two-sector ATPase complex]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 196 aa
22.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.